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   Comparison of the Effects of Nika Vaginal Cream With Clotrimazole Cream on Vaginal Candidiasis Symptoms: A Randomized Single Blind Clinical Trial  
   
نویسنده Parsapour Hamideh ,Masoumi Zahra ,Shayan Arezoo ,Moradkhani Shirin ,Ghiasian Amir ,Rashidi Mohammad Kazem
منبع Iranian Journal Of Nursing And Midwifery Research - 2021 - دوره : 26 - شماره : 6 - صفحه:521 -525
چکیده    Background: the prevalence of vaginal candidiasis is high in women and proper treatment is essential in this regard. materials and methods: this single‑blind randomized controlled clinical trial was conducted on 120 women who were referred to hamadan health centers in 2019. the patients were randomly divided into clotrimazole cream and nika vaginal cream groups each including 60 cases. the intervention group received nika vaginal cream once a day for a week and those in the control group were given clotrimazole vaginal cream in the same way. the clinical symptoms were studied by clinical examinations and the culture of vaginal discharge before and 7 days after the treatment to confirm the diagnosis of candida albicans. the results were analyzed by spss 21.0 using an independent t test, mann– whitney u test, and chi‑square, fisher’s exact, and mcnemar’s tests, the significance level was set at 0.05. results: most patients in both groups reported no clinical symptoms after the intervention, and no significant difference was observed between the two groups in this regard (χ2 = 2.23, p = 0.566). conversely, a significant difference was found in nika and clotrimazole groups before and after the intervention regarding improving vulvovaginal candidiasis (vvc) symptoms χ2 = 86.01, χ2 = 99.41, respectively (p < 0.001). finally, 84.48% and 75.86% of women in the nika χ2 = 45.02 (p < 0.001) and clotrimazole cream χ2 = 40.02 (p < 0.001) groups had negative culture results after the intervention. conclusions: in general, the nika and clotrimazole vaginal creams have the same effects concerning improving the symptoms of vaginal candidiasis and thus can be used to treat vvc.
کلیدواژه Candidiasis ,Honey ,Iran ,Olea ,Propolis ,Vulvovaginal
آدرس Hamadan University Of Medical Sciences, Fatemieh Hospital, Department Of Gynecology, Clinical Research Development Unit, Iran, Hamadan University Of Medical Sciences, Mother And Child Care Research Center, School Of Nursing And Midwifery, Iran, Hamadan University Of Medical Sciences, Mother And Child Care Research Center, School Of Nursing And Midwifery, Department Of Midwifery And Reproductive Health, Iran, Hamadan University Of Medical Sciences, School Of Pharmacy, Medicinal Plants And Natural Products Research Center, Department Of Pharmacognosy, Iran, Hamadan University Of Medical Sciences, School Of Medicine, Psoriasis Research Center, Farshchian Hospital, Medical Parasitology And Mycology Department, Department Of Dermatology, Iran, Nika Research And Traditional Medicine Production Company, Iran
 
 

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