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Simultaneous Determination of Atenolol and Propranolol in Pharmaceutical Formulations By Third Derivative Spectrophotometric Method
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نویسنده
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Habibagahi Hadieh ,Sheibani Ali ,Shishehbore M. Reza
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منبع
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Iranian Journal Of Analytical Chemistry - 2016 - دوره : 3 - شماره : 1 - صفحه:70 -75
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چکیده
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In this study, a third derivative spectrophotometric method based on zero-crossing technique is developed for the simultaneous determination of atenolol and propranolol. effective parameters including temperature and ph were investigated and optimized. under optimum experimental conditions (temperature: 10 oc and ph: 8-10), calibration curves were linear between concentration ranges of 0.8 to 12.9 μg ml-1 of atenolol and 0.3 to 6.4 μg ml-1 of propranolol. the limit of detection was 0.2 μg ml-1 and relative standard deviation was lower than 3%. the proposed method was applied for the simultaneous determination of both drugs in the pharmaceutical formulations. acceptable recoveries of the analytes, ranging from 97 to 107%, were obtained
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کلیدواژه
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Atenolol; Propranolol; Derivative Spectrophotometry; Zero-Crossing.
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آدرس
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Islamic Azad University, Yazd Branch, Department Of Chemistry, ایران, Islamic Azad University, Yazd Branch, Department Of Chemistry, ایران, Islamic Azad University, Yazd Branch, Department Of Chemistry, ایران
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تعیین همزمان آتنولول و پروپرانولول در نمونه های دارویی به روش اسپکتروفتومتری مشتقی مرتبه سوم
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Authors
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شیبانی علی ,شیشه بر مسعودرضا ,حبیب آگهی هدیه
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