>
Fa   |   Ar   |   En
   Alterations in Humoral Immunity After Partial Versus Total Tonsillectomy: A Pilot Study and Systematic Review of Literature  
   
نویسنده Bitar Mohamad A. ,Rameh Charbel ,Ataya Nour F. ,Najarian Alik ,Chakhtoura Marita ,Abdelnoor Alexander
منبع Journal Of Pediatrics Review - 2016 - دوره : 4 - شماره : 2 - صفحه:1 -12
چکیده    Background: the palatine tonsils are secondary lymphoid organs, important in sampling antigens directly from the epithelial surfaces. they produce antibodies locally and distally through their migrating b cells. objectives: the aim of this study was to compare the changes in serum and saliva immunoglobulin (ig) levels after total vs. partial tonsillectomy and also to systematically review the literature regarding the changes in humoral immunity following tonsillar surgery. patients and methods: children with obstructive tonsils were recruited in a pilot study and randomized to undergo total or partial tonsillectomy. blood and saliva samples were obtained immediately preoperatively and within 3 months postoperatively, to measure serum ig (g, m and a) and saliva secretory iga concentrations. patients’ clinical history was reviewed at one year postoperatively. systematic literature review regarding the effects of tonsillar surgery on humoral immunity was performed, using medline, embase and cochrane. results: nineteen patients completed the study (11 partial, 8 total). no statistically significant changes noted in the serum ig’s level in both groups, except for igm which increased (p = 0.018) after partial tonsillectomy, mainly in males (p = 0.04), and in those aged 5 years and older (p = 0.02). there was noticeable decrease in susceptibility to infections. four out of 30 studies (406 out of 1796 patients) showed decrease in some elements of the humoral immunity or suspected a negative impact of tonsillectomy on the immune system. conclusions: partial tonsillectomy does not seem to offer an immunological advantage over total tonsillectomy. the literature does not imply a significant negative impact of tonsillectomy on the humoral immune system.
کلیدواژه Humoral Immunity ,Partial Vs ,Total Tonsillectomy ,Serum And Saliva Immunoglobulin
آدرس American University Of Beirut, Faculty Of Medicine And Medical Center, Department Of Pediatrics And Adolescent Medicine, Department Of Otolaryngology Head And Neck Surgery, Lebanon. Sydney University, Children’S Hospital At Westmead, Department Of Ent Surgery, Australia. Al-Jalila Children’S Specialty Hospital, Pediatric Otolaryngology Program, United Arab Emirates, American University Of Beirut, Faculty Of Medicine And Medical Center, Department Of Otolaryngology Head And Neck Surgery, Lebanon, American University Of Beirut, Faculty Of Medicine And Medical Center, Department Of Microbiology, Lebanon, American University Of Beirut, Faculty Of Medicine And Medical Center, Department Of Microbiology, Lebanon, American University Of Beirut, Faculty Of Medicine And Medical Center, Department Of Microbiology, Lebanon, American University Of Beirut, Faculty Of Medicine And Medical Center, Department Of Microbiology, Lebanon
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved