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   searching for alpha-glucosidase inhibitory activity in hexane extracts by some plants from kurdistan province  
نویسنده zarei mohammad ali ,poursharifi mina
منبع international journal of advanced biological and biomedical research - 2015 - دوره : 3 - شماره : 3 - صفحه:291 -296
چکیده    objective: alpha-glucosidase, as a carbohydratase catalyses the liberation of alpha-glucose from the nonreducing end of some carbohydrates from foods in digestive tract.  consequently, retard absorption of glucose by the inhibition of carbohydrate hydrolyzing enzymes is one of the therapeutic approaches to decrease the postprandial hyperglycemia. recently, a great deal of attention has been paid to natural products like plants, as a reliable source for bioactive compounds.the aim of this study was to find new potent inhibitors for alphaglucosidase among plant extracts. methods: hexan extracts of 60 plants species were screened for their alphaglucosidase inhibitory activity at 0.001, 0.01, 0.1 and 1 mg/ml concentration. acarbose, dissolved in buffer, was used as a positive control. every experiment was done in triplicate.descurania sophia (l.) webb & berth, fumaria vailantii loisel, ferula haussknechti wolf ex rech,haplophyllum acutifolium (dc.)g.don, isatis cappadociaca desv., eremostachys laevigata bunge, silene aucheriana boiss exhibited more than 60% alpha-glucosidase inhibitory activity.. results: among them, descurania sophia, fumaria vailantii and ferula haussknechti exhibited significant alpha glucosidase inhibitory activity with ic50 values of 0.9 µg/ml, 24.55 µg/ml and 2.71 µg/ml, respectively. because of its high inhibitory activity and low ic50, descurania sophia extract would be interesting for further studies
کلیدواژه alpha-glucosidase ,inhibitor ,plant extract ,hexane ,diabetes mellitus
آدرس university of kurdistan, faculty of science, department of biological sciences and biotechnology, ایران, university of kurdistan, faculty of science, department of biological sciences and biotechnology, ایران
پست الکترونیکی mpoursharifi@ymail.com

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