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   Primaquine Decreased Plasma Concentration of Ritonavir: Single- and Repeated-Dose Study in Sprague Dawley Rats  
   
نویسنده Louisa Melva ,Soetikno Vivian ,Nafrialdi ,Setiabudy Rianto ,Suyatna Frans D.
منبع Medical Journal Of Indonesia - 2011 - دوره : 20 - شماره : 3 - صفحه:190 -194
چکیده    Background: the present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledose or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats. methods: in single-dose study, 30 male spraque dawley rats were randomly allocated to receive ritonavir 20 mg/kg bw or ritonavir 20 mg/kg bw + primaquine 1.2 mg/kg bw or ritonavir 20 mg/kg bw + ketokonazole 10 mg/kg bw. ketokonazole was used as positive control of ritonavir metabolism inhibitor. in the repeated-dose study, thirty spraque dawley male rats were randomly allocated to receive ritonavir 20 mg/kg bw/day or ritonavir 20 mg/kg bw/day + primaquine 1.2 mg/kg bw/ day or ritonavir 20 mg/kg bw/day + rifampicin 100 mg/kg bw/day. rifampicin was used as a positive control of ritonavir metabolism inducer. results: in the single-dose study, ketokonazole increased the area under the plasma concentration (auc) of ritonavir (↑ 114.8%, p< 0.05), while primaquine tended to decrease the auc of ritonavir (↓ 32.6%, p> 0.05). repeated-dose study showed that rifampicin decreases the auc of ritonavir (↓ 42.8%, p< 0.001), and primaquine decreased the auc of ritonavir plasma concentration (↓ 46.6%, p< 0.001). conclusion: concomitant administration of primaquine and ritonavir decreases the auc of ritonavir. this effect may result in the insuffi cient concentration of ritonavir as anti-hiv, which may lead to treatment failure with ritonavir. (med j indones 2011; 20:190-4)
کلیدواژه Drug Interaction ,Metabolism ,Primaquine ,Ritonavir
آدرس University Of Indonesia, Faculty Of Medicine, Department Of Pharmacology And Therapeutics, Indonesia, University Of Indonesia, Faculty Of Medicine, Department Of Pharmacology And Therapeutics, Indonesia, University Of Indonesia, Faculty Of Medicine, Department Of Pharmacology And Therapeutics, Indonesia, University Of Indonesia, Faculty Of Medicine, Department Of Pharmacology And Therapeutics, Indonesia, University Of Indonesia, Medical Faculty, Department Of Pharmacology And Therapeutics, Indonesia
 
 

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