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   Genotype Distribution of T Cell Receptor Β Gene in Indonesian Nasopharyngeal Carcinoma Patients  
   
نویسنده Yurnadi ,Soeharso Purnomo ,Suryandari Dwi A. ,Moeloek Nukman ,Susworo R.
منبع Medical Journal Of Indonesia - 2011 - دوره : 20 - شماره : 3 - صفحه:171 -177
چکیده    Background: nasopharyngeal carcinoma (npc) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. besides infection with ebv, genetic factors such as polymorphisms of tcr-β gene contribute to the incidence of npc. this study investigates the association of tcr-β gene polymorphisms with individual susceptibility to develop npc in indonesian ethnic groups. methods: the study was carried out by the pcr-rflp method using bgl ii restriction enzyme to digest tcr-β gene. the pcr-rflp analysis of tcr-β gene was used to determine allotypes of tcr-β gene in npc patients and control among ethnic chinese and indigenous groups in the population of indonesia. results: the results indicate that the distribution of tcr-β gene allotypes between npc patients and controls are not significantly different (p > 0.05); however, the frequency of a allele tends to increase in npc patients. the distribution of tcr-β gene allotypes between chinese ethnic group was not significantly different from indigenous groups (p > 0.05). conclusion: the distribution of tcr-β gene allele between npc group and control groups showed no difference. the distribution of tcr-β gene between ethnic chinese and indigenous groups showed no difference. polymorphisms of tcr-β gene are not associated with npc and ethnic groups in indonesian population. (med j indones 2011; 20:171-7)
کلیدواژه Ebv ,Npc ,Polymorphism ,Susceptibility ,Tcr-ß Gene
آدرس University Of Indonesia, Faculty Of Medicine, Department Of Medical Biology, Program Doctoral Medical Biology, Indonesia, University Of Indonesia, Faculty Of Medicine, Department Of Medical Biology, Indonesia, University Of Indonesia, Faculty Of Medicine, Department Of Medical Biology, Indonesia, University Of Indonesia, Faculty Of Medicine, Department Of Medical Biology, Indonesia, University Of Indonesia, Faculty Of Medicine, Ciptomangunkusumo Hospital, Department Of Radiotherapy, Indonesia
 
 

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