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Solvent-Free Preparation of Novel 2-[Phenyl (Pyridine-2-Ylamino) Methyl] Phenols As Pseudo-Betti Processor For Natural Products
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نویسنده
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Shushizadeh Mohammad Reza ,Azizyan Somaye
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2014 - دوره : 9 - شماره : 4 - صفحه:1 -4
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چکیده
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Background: 2-aminopyridine and benzaldehydes mixture readily reacted with phenols at 80°c without any solvents to produce novel 2-[phenyl (pyridine-2-yl amino (methyl] phenol derivatives as pseudo-betti products in good to high yields. these compounds are efficient processor for synthesis of the natural products. objectives: we decided to report the synthesis of a series of novel n-heteroaryl-arylmethyl phenols via a simple three-component,one-pot method,using aromatic aldehydes,heteroaryl amines,and phenols in the absence of any acid catalysts and under solvent-free conditions. materials and methods: all starting materials were purchased from merck and aldrich companies. the ir spectra were recorded on a perkin-elmer rxi infrared spectrometer. results: the reaction is convenient,operationally simple,proceeds quickly,and does not need solvents or expensive starting materials. the structures of the products were characterized by their spectral (1h nmr and ir) data. conclusions: we have developed a new,simple,and efficient method for one-pot aminoalkylation of active phenol compounds with various imines prepared from 2-aminopyrimidine and benzaldehydes in good to high yields (40%-97%). © 2014,school of pharmacy,ahvaz jundishapur university of medical sciences.
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کلیدواژه
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Solvent-Free; Pseudo-Betti; Base; 2-Amino Pyridine; Phenols
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آدرس
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Ahvaz Jundishapur University Of Medical Sciences, Marine Pharmaceutical Science Research Center, Department Of Medicinal Chemistry, ایران, Islamic Azad University, Khuzestan Sciences And Research Branch, ایران
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Authors
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