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The Effects of Hydroalcoholic Extract of Apium Graveolens Leaf on the Number of Sexual Cells and Testicular Structure in Rat
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نویسنده
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Kooti Wesam ,Mansouri Esrafil ,Ghasemiboroon Maryam ,Harizi Mahmoud ,Ashtary-Larky Damoon ,Afrisham Reza
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2014 - دوره : 9 - شماره : 4 - صفحه:1 -6
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چکیده
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Background: use of medicinal plants with high antioxidant properties could be effective to increase fertility and improvement of disorders such as hormonal imbalance,impotency,oligospermia and immotile sperm. celery (apium graveolens) is rich in antioxidant agents. the leaf and stems of celery contain phenols,furanocoumarin and luteolin. apigenin is one of the main flavonoids of celery leaf. objectives: this study aimed to investigate the effects of hydroalcoholic extract of celery on histological properties of testis and number of sexual cells in male rats. materials and methods: thirty-two male wistar rats were divided into four groups of eight rats each. control,did not receive any medication; sham,received normal saline and two groups received celery extract orally in dosages of 100 and 200 mg/kg/bw once every two days for 60 days. at the end,animals were anesthetized,and caudal part of the right epididymis was used for sperm counting. after fixation of testis,tissue sections were prepared and studied microscopically to evaluate morphometric (lumen diameter,number of primary spermatocyte and sertoli cell) and histological changes. data was analyzed by one-way anova test using spss15 software. p < 0.05 was considered as statistically significant. results: there was a significant increase in the number of sperms,sertoli cells,and primary spermatocyte (p < 0.05) in groups receiving extract; however,structural changes were not observed in the groups. conclusions: it seems that celery increases spermatogenesis in male rats,but has no destructive effects on testicular tissue. © 2014,school of pharmacy,ahvaz jundishapur university of medical sciences.
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کلیدواژه
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Apium Graveolens; Testicular Structure; Rat; Extract
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آدرس
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Kurdistan University Of Medical Sciences, School Of Medicine,, Department Of Immunology,Student Research Committee, ایران, Ahvaz Jundishapur University Of Medical Sciences, Cellular And Molecular Research Center,School Of Medicine, Department Of Anatomical Sciences, ایران, Ahvaz Jundishapur University Of Medical Sciences, Student Research Committee, ایران, Ahvaz Jundishapur University Of Medical Sciences, Student Research Committee, ایران, Ahvaz Jundishapur University Of Medical Sciences, School Of Medicine, Student Research Committee,Department Of Clinical Biochemistry, ایران, Ahvaz Jundishapur University Of Medical Sciences, Student Research Committee, ایران
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Authors
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