|
|
|
|
Preparation of Chlorpheniramine Maleate-Loaded Alginate/Chitosan Particulate Systems By the Ionic Gelation Method For Taste Masking
|
|
|
|
|
|
|
|
نویسنده
|
Jelvehgari Mitra Jelvehgari ,Barghi Leila ,Barghi Farhad
|
|
منبع
|
Jundishapur Journal Of Natural Pharmaceutical Products - 2014 - دوره : 9 - شماره : 1 - صفحه:39 -48
|
|
|
|
|
چکیده
|
Background: chlorpheniramine maleate (cm) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/ disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. objectives: the purpose of this research was to mask the bitter taste of cm by formulating microspheres of the taste-masked drug. materials and methods: this work was done to develop alginate/chitosan particles prepared by ionic gelation (ca2+ and al3+) for the cm release. the effect of different chitosan and ca2+ concentrations on taste masking and the characteristics of the microspheres were investigated. ca2+ and al3+ alginates microspheres of cm were prepared using cross-linked insoluble complexes that precipitate,incorporating the drug. formulations were characterized for particle size and shape,entrapment efficiency,fourier transform spectroscopy (ftir),x-ray diffraction (xrd),and differential scanning calorimetry (dsc),bitter taste threshold and in vitro drug release in simulated gastrointestinal fluids. results: ftir,xrd and dsc demonstrated unstable characters of cm in the drug-loaded microspheres and revealed an amorphous form. also,the peak of alginate microparticles (ca2+ and al3+ ions) in all formulations remained the same,with low intensity of spectrum. the results of dsc,x-ray diffraction and ftir showed the presence of several cm chemical interactions with alginate and ions (ca2+ and al3+). the microsphere formulations showed desirable drug entrapment efficiencies (62.2-94.2%). calcium/aluminum alginate retarded the release of cm at low ph = 1.2 and released the drug from microspheres slowly at ph = 6.8,simulating intestine ph. the drug release duration and the release kinetics were dependent on the nature of the polymers,the cation concentrations,and valences (ca2+ and al3+). the drug release rate was decreased by an increase in chitosan and cation concentrations. conclusions: the results of the present study indicated that oral preparation of cm with an acceptable taste is feasible. © 2014,school of pharmacy,ahvaz jundishapur university of medical sciences.
|
|
کلیدواژه
|
Chlorpheniramine; Calcium; Aluminium; Taste
|
|
آدرس
|
Tabriz University Of Medical Sciences, Drug Applied Research Center,Faculty Of Pharmacy, ایران, Tabriz University Of Medical Sciences, Faculty Of Pharmacy, ایران, Tabriz University Of Medical Sciences, Student Research Committee, ایران
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|