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Preventive Effects of Pomegranate Seed Extract Pulmonary Fibrosis in Rat
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نویسنده
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Hemmati Ali Asghar ,Rezaie Annahita ,Darabpour Pegah
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2013 - دوره : 8 - شماره : 2 - صفحه:76 -80
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چکیده
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Background: oxidative stress plays an important role in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been used for the treatment of this disease in animals. objectives: to evaluate the antioxidant effects of pomegranate seed extract (pse) on bleomycin treated rats. materials and methods: male spraque - dawley rats were divided into 5 groups: rats in groups i (bleomycin) and ii (control) were given a single dose of bleomycin (7.5 iu/kg,intratracheally) in the bleomycin group and same amount of saline in the control,respectively. treatment groups (iii-v) were given pse (100,200,400 mg/kg) orally a week before the bleomycin injection and this was continued for 3 weeks. at day 28,animals were sacrificed and lungs were removed for histological investigation. results: histological analysis showed that pse could prevent pathological changes that were seen in the bleomycin group. conclusions: results of the present study showed that hydroalcoholic extracts of pomegranate seeds had a significant protective effect against bleomycin-induced lung fibrosis by its antioxidant properties. the highest protective effect was observed for the 400 mg/kg dose. © 2013,school of pharmacy,ahvaz jundishapur university of medical sciences; published by docs.
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کلیدواژه
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Pulmonary Fibrosis; Bleomycin; Antioxidants
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آدرس
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Ahvaz Jundishapur University Of Medical Sciences, School Of Pharmacy, ایران, Shahid Chamran University Of Ahvaz, Faculty Of Veterinary Medicine,, Department Of Pathology,, ایران, Ahvaz Jundishapur University Of Medical Sciences, School Of Pharmacy, ایران
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Authors
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