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The Antioxidant Capacity and Anti-Diabetic Effect of Boswellia Serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys
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نویسنده
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Azemi Mohamad Ebrahim ,Namjoyan Foroogh ,Khodayar Mohammad Javad ,Ahmadpour Forouzan ,Darvish Padok Azam ,Panahi Marziyeh
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2012 - دوره : 7 - شماره : 4 - صفحه:168 -175
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چکیده
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Background: boswellia serrata has been used in a wide variety of diseases,including diabetes mellitus and inflammatory diseases. objectives: this study focused on the effects of boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examined the impact of plant on reproduction in diabetic rats. materials and methods: the antioxidant capacity of plant extract was performed using frap assay. diabetic and control rats were administered 200,400,and 600 mg/kg boswellia serrata extract. vaginal plaque was mentioned as a positive sign of pregnancy;and treatment started with extract or vehicle from 1th to 17th day of gestation by gastric gavage. blood glucose was measured during 17 days. results: the administration of boswellia serrata in diabetic rats significantly decreased the level of blood glucose and hba1c after 17th days (p ≤ 0.01). in diabetic group that received no treatment,the abortion of fetus spontaneous was 19.14%. the percentage of absorptions significantly was elevated in vehicle-treated diabetic rats,in comparison with vehicle- treated healthy rats. in the diabetic group,separated necrosis of hepatocytes,anarchism of liver plates,and lymphocytic inflammation were improved. diabetic complications were not seen and the severity of damage was reduced. these damages include: lymphocytic inflammation in the port areas,irregularities,apoptosis of liver cells,and dilatation of the sinusoids. conclusions: the results suggest that boswellia serrata extract has the antidiabetic effects and can prevent the complications of diabetes in the kidneys and liver. © 2012 school of pharmacy,ahvaz jundishapur university of medical sciences; published by kowsar corp.
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کلیدواژه
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Boswellia Hypoglycemic Agents Diabetes Complications Rats Antioxidants Histology
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آدرس
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Ahvaz Jundishapur University Of Medical Sciences, Medicinal Plant Research Center, School Of Pharmacy, Department Of Pharmacognosy, ایران, Ahvaz Jundishapur University Of Medical Sciences, Medicinal Plant Research Center,School Of Pharmacy, Marine Pharmaceutical Research Center, Department Of Pharmacognosy, ایران, Ahvaz Jundishapur University Of Medical Sciences, Toxicology Research Center,School Of Pharmacy, Department Of Toxicology-Pharmacology, ایران, Ahvaz Jundishapur University Of Medical Sciences, School Of Pharmacy, ایران, Ahvaz Jundishapur University Of Medical Sciences, School Of Pharmacy, ایران, Ahvaz Jundishapur University Of Medical Sciences, School Of Medicine, Department Of Anatomy, ایران
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Authors
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