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Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green Tea in the Formalin Test in Rats
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نویسنده
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Ghorbanzadeh Behnam ,Arzi Ardeshir ,Nazari Khorasgani Zahra
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2013 - دوره : 8 - شماره : 1 - صفحه:10 -14
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چکیده
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Background: tea (camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. littlescientific evidence exists in literature on the effect of this plant on pain. objectives: to investigate the antinociceptive activity of iranian green tea extract. materials and methods: the hydroalcoholic extract was administered to male wistar rats. formalin paw test was used to evaluate theantinociceptive activity. plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min beforethe subplantar formalin injection. results: the extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200mg /kg, i.p.) of formalin induced nociception. the results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (p < 0.001) reversed antinociception by green tea extract (gte) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1. conclusions: these results indicate that gte produces dose-related antinociception in chemical pain model and one of its possiblemechanisms involves opioid pathways.
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کلیدواژه
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Green Tea ,Antinociception ,Formalin Test ,Rat
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آدرس
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Ahvaz Jundishapur University Of Medical Sciences, Department Of Pharmacology And Toxicology, School Of Pharmacy, Jundishapur University Of Medical Sciences, Ahvaz, Ir Iran, ایران, Ahvaz Jundishapur University Of Medical Sciences, Department Of Pharmacology And Toxicology, School Of Pharmacy, Physiology Research Center, Jundishapur University Of Medical Sciences, Ahvaz, Ir Iran, ایران, Ahvaz Jundishapur University Of Medical Sciences, Department Of Pharmacology And Toxicology, School Of Pharmacy, Jundishapur University Of Medical Sciences, Ahvaz, Ir Iran, ایران
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Authors
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