|
|
|
|
Preparation and Evaluation of Physicochemical Properties of the Doxepin Mucoadhesive Gel
|
|
|
|
|
|
|
|
نویسنده
|
Rajaee Majid ,Talachi Amir ,Pardakhty Abbas ,Mohajeri Ehsan ,Dehghannoudeh Negar ,Basir Mohammadzaman ,Dehghannoudeh Gholamreza ,Lari Najafi Moslem
|
|
منبع
|
Jundishapur Journal Of Natural Pharmaceutical Products - 2020 - دوره : 15 - شماره : 4 - صفحه:1 -7
|
|
|
|
|
چکیده
|
Background: oral mucositis is a common debilitating complication of cancer chemotherapy and radiotherapy that can reduce the quality of patient’s lives. hence, treating this condition plays an important role in increasing the patient’s tolerance. objectives: doxepin mucoadhesive gel is useful for treating oral mucosa inflammation caused by longterm effects of chemotherapy, which has low adverse effects. methods: doxepin gel’s formulation was prepared with various concentrations of poloxamer 407 and hydroxypropyl methylcellulose in deionized water. the prepared gels were evaluated for ph, appearance, viscosity, spreadability, stability, and drug release.results: after providing gels containing doxepin, formulations 1, 2, 8, and 9 had low quality and, thus, were removed from the study. based on qualitative evaluations, formulations 3 and 4 did not meet the criteria for mucoadhesive gel and were removed from the study. the best formulation contained 17% w/w poloxamer 407, 10% w/w hydroxypropyl methylcellulose, and 5% w/w doxepin. conclusions: suitable physicochemical properties of prepared doxepin mucoadhesive gel enable it to well cover inflamed and damaged oral mucosa. on the other hand, doxepin’s slow release from formulation (8 hours) can increase therapeutic effects and reduce side effects, which can heal and soothe inflammations of the oral mucosa and be useful in cancer patient’s treatment.
|
|
کلیدواژه
|
Mucositis ,Mucoadhesive ,Doxepin ,Poloxamer 407 ,Viscosity ,Stability Study
|
|
آدرس
|
Kerman University Of Medical Sciences, Faculty Of Pharmacy, Pharmaceutics Department, Iran, Kerman University Of Medical Sciences, Faculty Of Pharmacy, Pharmaceutics Department, Iran, Kerman University Of Medical Sciences, Faculty Of Pharmacy, Pharmaceutics Department, Iran, Kerman University Of Medical Sciences, Faculty Of Pharmacy, Pharmaceutics Department, Iran, University Of Toronto, Faculty Of Arts And Science, Canada, Kerman University Of Medical Sciences, Pharmaceutics Research Center, Institute Of Neuropharmacology, Iran, Kerman University Of Medical Sciences, Faculty Of Pharmacy, Pharmaceutics Department, Iran, Kerman University Of Medical Sciences, Pharmaceutics Research Center, Institute Of Neuropharmacology, Iran
|
|
پست الکترونیکی
|
drlarinajafi@gmail.com
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|