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Protective Effects of Morin Against Bleomycin-Induced Pulmonary Fibrosis in Mice
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نویسنده
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Hemmati Ali Asghar ,Pashmforosh Marzieh ,Tabandeh Mohammad Reza ,Rezaie Anahita ,Rajabi Vardanjani Hossein ,Pipelzadeh Mohammad Hasan ,Sistani Karampour Neda
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2019 - دوره : 14 - شماره : 4 - صفحه:1 -8
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چکیده
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Background: idiopathic pulmonary fibrosis (ipf) is a fatal and incurable lung disease. morin, a natural product with antioxidant and anti-inflammatory activity, could reduce lung inflammation induced by lipopolysaccharide (lps) and liver fibrosis in previous studies. objectives: the aim of this study was to evaluate the antifibrotic activity of morin in the pulmonary fibrosis induced by bleomycin in mice. methods: pulmonary fibrosis was induced by the intratracheal instillation of bleomycin (3 mg/kg) in c57bl/6j mice. morin (10, 20, and 40 mg/kg, p.o.) was given to mice from day 0 to 21 after bleomycin administration. the mice were sacrificed on day 21 to measure the total number of cells, the percentage of leukocytes in bronchoalveolar lavage fluid (balf), lung hydroxyproline content, lung index, and oxidative stress markers. histopathological changes were evaluated by the microscopic examination of sections stained with hematoxylin-eosin and masson’s trichrome. results: our data showed that treatment with morin significantly attenuated the infiltration of inflammatory cells, hydroxyproline content, lung index, and oxidative stress that were elevated in fibrotic lungs. in addition, morin could reduce the pathological changes induced by bleomycin. conclusions: based on the study, morin, probably by its anti-inflammatory and antioxidant activities, can attenuate pulmonary fibrosis induced by bleomycin in mice.
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کلیدواژه
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Morin ,Pulmonary Fibrosis ,Bleomycin ,Oxidative Stress ,Mice
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آدرس
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Ahvaz Jundishapur University Of Medical Sciences, Medicinal Plant Research Center, School Of Pharmacy, Department Of Pharmacology, Iran, Ahvaz Jundishapur University Of Medical Sciences, Medicinal Plant Research Center, School Of Pharmacy, Department Of Pharmacology, Iran, Shahid Chamran University Of Ahvaz, Faculty Of Veterinary Medicine, Stem Cells And Transgenic Technology Research Center, Department Of Basic Sciences, Division Of Biochemistry, Iran, Shahid Chamran University Of Ahvaz, Faculty Of Veterinary Medicine, Department Of Pathobiology, Iran, Ahvaz Jundishapur University Of Medical Sciences, Medicinal Plant Research Center, Iran, Ahvaz Jundishapur University Of Medical Sciences, School Of Pharmacy, Department Of Pharmacology, Iran, Ahvaz Jundishapur University Of Medical Sciences, School Of Pharmacy, Department Of Pharmacology, Iran
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پست الکترونیکی
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n.sistani1386@yahoo.com
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Authors
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