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Zataria Multiflora Alleviates Cisplatin-Induced Oxidative Stress, Apoptosis, and Nephrotoxicity in Mice
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نویسنده
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Karimi Shokooh ,Talebpour Amiri Fereshteh ,Khalatbary Ali Reza ,Mohammadi Hamid Reza ,Hosseinimehr Jalal
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2019 - دوره : 14 - شماره : 3 - صفحه:1 -7
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چکیده
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Background: cisplatin (cp), as an anticancer drug, causes nephrotoxicity. zataria multiflora boiss (zm), a medicinal plant, has antioxidant and anti-inflammatory properties. objectives: the current study investigated the effects of zm on cisplatin-induced nephrotoxicity. methods: in the current experimental study, 22 male mice were randomly divided into four groups: the control; the zm, 200 mg/kg during seven days via gavage; the cp, 10 mg/kg intraperitoneally on the 5th day of study; and the zm + cp. serum creatinine and urea levels, malondialdehyde (mda), glutathione (gsh) and protein carbonyl (pc) levels in renal tissue of mice were histopathologically and immunohistochemically assessed to determine nephrotoxicity. results: cp caused a significant increase in serum creatinine and urea levels, increased oxidative stress in kidney tissue, caused histological changes, and increased caspase-3 immunoreactivity. zm significantly mitigated the toxic effects of cp on the kidney tissue. in addition, treatment with zm significantly reduced immunoreactivity of caspase-3. conclusions: the findings of the present study suggested that the zm as a potential antioxidant compound with scavenging free radicals and anti-apoptosis property attenuated the nephrotoxicity induced by cisplatin.
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کلیدواژه
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Cisplatin ,Nephrotoxicity ,Caspase-3
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آدرس
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Mazandaran University Of Medical Sciences, Molecular And Cell Biology Research Center, Faculty Of Medicine, Student Research Committee, Department Of Anatomy, Iran, Mazandaran University Of Medical Sciences, Molecular And Cell Biology Research Center, Faculty Of Medicine, Department Of Anatomy, Iran, Mazandaran University Of Medical Sciences, Molecular And Cell Biology Research Center, Faculty Of Medicine, Department Of Anatomy, Iran, Mazandaran University Of Medical Sciences, Faculty Of Pharmacy, Pharmacutical Sciences Research Center, Department Of Toxicology And Pharmacology, Iran, Mazandaran University Of Medical Sciences, Faculty Of Pharmacy, Department Of Radiopharmacy, Iran
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پست الکترونیکی
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sjhosseinim@yahoo.com
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Authors
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