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Some Systemic Effects of Deuterium Depleted Water on Presenile Female Rats
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نویسنده
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Dzhimak Stepan Sergeevich ,Shikhliarova Alla Ivanovna ,Zhukova Galina Vitalievna ,Basov Alexandr Alexandrovich ,Kit Oleg Ivanovich ,Fedulova Liliya Viacheslavovna ,Kurkina Tatiana Anatolievna ,Shirnina Elena Alekseevna ,Protasova Tatiana Panteleevna ,Baryshev Mikhail Gennadievich ,Timakov Alexandr Alekseevich
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منبع
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Jundishapur Journal Of Natural Pharmaceutical Products - 2018 - دوره : 13 - شماره : 3 - صفحه:1 -6
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چکیده
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Consumption of deuterium depleted water (ddw) (46 ± 2 ppm) as drinking water by white outbred female rats (20 - 22 months) during five weeks led to the development of a well-pronounced geroprotector effect, which manifested in occurrence of the estrous cycle restoration signs, as well as in the coat state improvement, compared with the same characteristics of animals that received drinking water with a deuterium content of 150 ppm. besides, rats receiving ddw showed the improvement of the skin bacteri- cidal power. thus, experiments in mammals provided a direct confirmation of the geroprotector properties of ddw. the current study revealed a deuterium content reduction in blood (according to the nmr (nuclear magnetic resonance) spectroscopy data) and visceral organs: liver, kidney, and heart (according to the mass spectroscopy data) in animals receiving ddw. a more pronounced decrease in the deuterium content was recorded in the rat blood plasma (33.2%) compared with the deuterium content changes in visceral organs (liver -7.2%, kidney -9.7%, heart -7.3%), which generally led to a change in the direction of the d/h isotopic gradient with consumption of ddw by the animals (cd blood plasma < cd visceral organs ).
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کلیدواژه
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Deuterium ,Nmr Spectroscopy ,Geroprotector Effect ,Anti-Stress Effect ,Anti-Stress Adaptation
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آدرس
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V.M. Gorbatov Federal Research Center For Food Systems Of Russian Academy Of Sciences, Experimental Clinic, Laboratory Of Biologically Active Substances Of Animal Origin, Russia. Kuban State University, Department Of Radiophysics And Nanotechnology, Russia, Rostov Research Institute Of Oncology, Testing Laboratory Centre, Russia, Rostov Research Institute Of Oncology, Testing Laboratory Centre, Russia, Kuban State University, Department Of Radiophysics And Nanotechnology, Russia. Kuban State Medical University, Department Of Fundamental And Clinical Biochemistry, Russia, Rostov Research Institute Of Oncology, Testing Laboratory Centre, Russia, V.M. Gorbatov Federal Research Center For Food Systems Of Russian Academy Of Sciences, Experimental Clinic, Laboratory Of Biologically Active Substances Of Animal Origin, Russia, Rostov Research Institute Of Oncology, Testing Laboratory Centre, Russia, Rostov Research Institute Of Oncology, Testing Laboratory Centre, Russia, Rostov Research Institute Of Oncology, Testing Laboratory Centre, Russia, Kuban State University, Department Of Radiophysics And Nanotechnology, Russia
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پست الکترونیکی
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timakov@author.com
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Authors
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