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   Prevalence of Short Stature, Underweight and Delayed Puberty in Iranian Patients With Thalassemia Major: A Systematic Review and Meta-Analysis  
   
نویسنده Badfar Gholamreza ,Parizad Nasirkandy Marzieh ,Shohani Masoumeh ,Mansouri Akram ,Shabani Ehsan ,Rahmati Shoboo ,Soleymani Ali ,Azami Milad
منبع Iranian Journal Of Pediatric Hematology And Oncology - 2017 - دوره : 7 - شماره : 4 - صفحه:245 -259
چکیده    Growth disorders are considered as one of the common complications of thalassemia major patients. the present study was conducted to examine the prevalence of short stature, underweight, and delayed puberty in patients with thalassemia major in iran. this review study was conducted based on systematic review and meta-analysis protocol (prisma) until 2017. to access relevant literature, two researchers independently searched magiran, medlib, iranmedex, sid, pubmed, scopus, sciencedirect, web of science, as well as google scholar search engine. pooled prevalence was calculated using a random effects model. data were analyzed using comprehensive meta-analysis software (version 2). in 18 studies, including 2,446 iranian thalassemia major patients, the prevalence of short stature was estimated to be 52.3% (95%ci: 45.7-58.8). the lowest prevalence of short stature was in the north of iran (42.4% [95%ci: 34.7-50.4]) and mazandaran province (31.8% [95%ci: 27.5-36.5]), and the highest prevalence was in the south (64.6% [95%ci: 51.2-72.1]) and fars province (71.4% [95%ci: 49.8-86.3]). the prevalence of short stature among males and females was estimated to be 48.7% (95%ci: 39.3-58.1) and 40.4% (95%ci: 30.4- 51.2), respectively, and male to female odds ratio was 1.21 (95%ci: 1.01-1.46, p=0.03). prevalence of delayed puberty and underweight in iranian thalassemia major patients were estimated to be 67.5% (95%ci: 46.8-83.1) and 47.6% (95%ci: 37.0-58.4), respectively. the results of this meta-analysis showed that the prevalence of short stature, delayed puberty, and underweight in iranian thalassemia major patients is very high. therefore, new planning and policies seem necessary to minimize the complications in patients with thalassemia major
کلیدواژه Delayed Puberty ,Growth Disorders ,Thalassemia
آدرس Behbahan Faculty Of Medical Sciences, Department Of Pediatrics, ایران, Tabriz University Of Medical Sciences, Women’S Reproductive Health Research Center, ایران, Ilam University Of Medical Sciences, Faculty Of Allied Medical Sciences, Department Of Nursing, ایران, Ahvaz Jundishapour University Of Medical Science, School Of Nursing And Midwifery, ایران, Ilam University Of Medical Sciences, School Of Health, Student Research Committee, ایران, Ilam University Of Medical Sciences, School Of Health, Student Research Committee, ایران, Dezful University Of Medical Sciences, ایران, Ilam University Of Medical Sciences, Faculty Of Medicine, Student Research Committee, ایران
 
 

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